Ultrastructure of the optic nerve in Krabbe's leucodystrophy.

Abstract

The leucodystrophies are a heterogeneous group of inherited neurological disorders all characterized by progressive symmetrical demyelination without any marked inflam- matory response, causing loss of motor, sensory, and intellectual functions with an eventual Light-microscopic studies (Norman, Oppenheimer, and Tingey, 196I; D'Agostino, Sayre, and Hayles, I963) have demonstrated that globoid cells tend to have a perivascular distribution within the cerebral white matter, and that they appear and increase in number during the period of myelin breakdown. Accumulations of periodic acid-Schiff-positive