Chemistry - An Asian Journal · 2006 · 132 citations · 34 references
PharmacyChemistryMedicinal ChemistryNatural Product BiosynthesisSynthetic Medicinal ChemistryHeterocycle SynthesisMacrocycle SynthesisMicrowave-assisted SynthesisOrganic SynthesisAutomated Synthesis ModulesMicrowave-assisted AlkylationMicrowave-assisted Organic SynthesisNatural Product Total Synthesis
A 36-step synthesis was carried out in automated synthesizers to provide a synthetic key intermediate of taxol. A key step involved a microwave-assisted alkylation reaction to construct the ABC ring system from an AC precursor. Subsequent formation of the D ring afforded baccatin III, a well-known precursor of taxol.
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K. C. Nicolaou, Zhen Yang, Jimei Liu et al. · Nature · 1994 · 1.1K citations
Gene Synthesis Machines: DNA Chemistry and Its Uses
Marvin H. Caruthers · Science · 1985 · 791 citations