EFFECTS OF INDOCYANINE GREEN INJECTION ON THE RETINAL SURFACE AND INTO THE SUBRETINAL SPACE IN RABBITS

Abstract

Subretinal delivery of ICG (5 mg/mL) in rabbits induces retinal pigment epithelium, photoreceptor inner and outer segment, and outer nuclear layer damage. These mechanisms of damage may explain the retinal pigment epithelium changes that are sometimes seen after ICG-assisted internal limiting membrane peeling in humans.