IMMUNOLOGICAL RESPONSES TO AN INTESTINAL ALLOGRAFT WITH HL-A-IDENTICAL DONOR-RECIPIENT

Abstract

SUMMARY Transplantation of an intestinal allograft from an HL-A-identical donor was free of technical complications. A mild rejection episode caused severe epithelial damage. A sharp increase in circulating IgM levels was present 10 days after transplantation. IgG and IgA values were not affected. Cytotoxic antibodies were not identified. Clinical findings suggestive of a possible graft-versus-host reaction were not substantiated by histopathological findings and by Gm differences existing between donor and recipient. Immunosuppression for clinical intestinal transplantation after massive intestinal resection is discussed.