Concepedia

Publication | Closed Access

Calpain activation by hepatitis C virus proteins inhibits the extrinsic apoptotic signaling pathway #

DOI

35

Citations

25

References

2009

Year

Yannick Simonin, Olivier Disson, Hervé Lerat, Etienne Antoine, Fabien Binamé, Arielle R. Rosenberg, Solange Desagher, Patrice Lassus, Paulette Bioulac‐Sage, Urszula Hibner
Hepatology

Abstract

Calpains activated by HCV proteins degrade Bid and thus dampen apoptotic signaling. These results suggest that inhibiting calpains could lead to an improved efficiency of immune-mediated elimination of HCV-infected cells.

References

YearCitations

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