The Influence of Assisted Reproductive Technology on Women with Pregnancy-induced Hypertension: A Retrospective Study at a Japanese Regional Perinatal Center

Abstract

OBJECTIVE: To evaluate clinical features of assisted reproductive technology (ART) patients with pregnancy-induced hypertension (PIH) compared to spontaneously conceived PIH patients. METHODS: We retrospectively compared PIH incidence, maternal outcomes, and neonatal outcomes among these patients. RESULTS: Preeclampsia, cesarean rate, and massive maternal bleeding were significantly more common in the ART group. Neonatal outcomes showed no significant difference between the groups. Multiple regression analysis revealed ART as an independent risk factor for preeclampsia. However, higher cesarean rate and massive bleeding were mainly associated with multiple pregnancy. CONCLUSION: ART patients with PIH had an increased incidence of preeclampsia, cesarean delivery, and massive maternal hemorrhage.