Influence of Liposome Type and Skin Model on Skin Permeation and Accumulation Properties of Genistein

Abstract

Abstract This article investigates the impact of elastic liposomes on enhancing the skin delivery of genistein and the influences of skin tissues with or without hair follicles on permeation and accumulation properties of genistein from liposomal suspensions. The greater permeation rate and deposition values of genistein were observed from the elastic liposomes than conventional liposomes in haired skin. When measured with hairless skin, the flux and skin deposition values of genistein in elastic liposomes were significantly decreased compared to conventional liposomes, indicating that the percutaneous delivery of elastic liposomes was considerably influenced by existence of hair follicles in the skin tissue. Keywords: Accumulationelastic liposomegenisteinpermeationskin This research was supported by the Chung-Ang University Research Grants in 2009. Notes *NA: not appeared. a PC: S = soya phosphatidyl choline: sodium deoxycholate. a P < 0.05: Significantly different from other vehicles.