Concepedia

Inhibition of export of fibroblast growth factor-2 (FGF-2) from the prostate cancer cell lines PC3 and DU145 by anvirzel and its cardiac glycoside component, oleandrin11Abbreviations: PARP, poly(ADP-ribose) polymerase; NF-κB, nuclear factor-κB; FGF-2, fibroblast growth factor-2; ER, endoplasmic reticulum; and MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide.

Judith A. Smith, Timothy Madden, Mary Vijjeswarapu, Robert A. Newman

Biochemical Pharmacology · 2001 · 103 citations · 14 references

DOI

Concepts

References

14

Cardiac glycosides stimulate Ca2+ increases and apoptosis in androgen-independent, metastatic human prostate adenocarcinoma cells.

David J. McConkey, Yun‐Lian Lin, Leta K. Nutt et al. · PubMed · 2000 · 282 citations

, , +15

Quantitative export of FGF‐2 occurs through an alternative, energy‐dependent, non‐ER/Golgi pathway

Robert Z. Florkiewicz, R A Majack, Robbie D. Buechler et al. · Journal of Cellular Physiology · 1995 · 211 citations

, , +13

Oleandrin suppresses activation of nuclear transcription factor-kappaB, activator protein-1, and c-Jun NH2-terminal kinase.

Sunil K. Manna, Nand K. Sah, Robert A. Newman et al. · PubMed · 2000 · 187 citations

, , +10

Understanding the sodium pump and its relevance to disease

Andrea M Rose, R Valdes · Clinical Chemistry · 1994 · 174 citations

, , +17

Digitoxin is a potential anticancer agent for several types of cancer

Johan Haux · Medical Hypotheses · 1999 · 168 citations

, , +8