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Lymphocytes from mice chronically infected with Theiler’s murine encephalomyelitis virus produce demyelination of organotypic cultures after stimulation with the major encephalitogenic epitope of myelin proteolipid protein. Epitope spreading in TMEV infection has functional activity

Myelin Proteolipid ProteinAutoimmune DiseaseMajor Encephalitogenic EpitopeMedicinePathogenesisImmunologyPathologyAutoimmunityT Cell ImmunityHumoral ImmunityImmune FunctionImmunologic DiseaseTmev InfectionBrain-immune InteractionImmune SystemNeuroimmunology