Role of Histamine H<sub>3</sub> and H<sub>4</sub> Receptors in Mechanical Hyperalgesia following Peripheral Nerve Injury

Abstract

We propose that the increase in mechanical hyperalgesia produced by thioperamide and JNJ 7777120 and the decrease in mechanical hyperalgesia produced by VUF 8430 may represent a direct effect of these agents on mechanospecific primary afferents, or an indirect effect of these agents via injury-induced inflammation.