Endocrinology · 1941 · 15 citations · 0 references
MedicineEndocrinologyVeterinary PhysiologyCanine Internal MedicineDiabetologyNeuroendocrinologyDiabetes MellitusInsulin TherapyMetabolic DisordersPancreatic EndocrinologyPituitary Gland FunctionPituitary HormonesAnterior Pituitary Hormone SecretionCanine Diabetes MellitusDiabetes Mellitus PathophysiologyFasting-state MetabolismInsulin ActionInsulin PhysiologyPancreatic DiabetesPituitary Physiology
THE OBSERVATION of Young (1) that permanent diabetes could be produced in dogs by the injection of anterior pituitary extract has been followed by numerous investigations. The present literature on this subject is fully cited in a recent paper by Marks and Young (2). Our initial report (3) on the production of diabetes in dogs by this method was based on the early results in 3 animals, and since that time 7 more dogs have been prepared. On the basis of a more adequate experience with these 10 animals further studies are here presented. These include additional observations on the induction of the permanent diabetes, and evidence for the pancreatic nature of the established diabetes based on the response to insulin, the fasting metabolism and the examination of the tissues. Also, the course of the permanent diabetes.has been charted and the possible influence of insulin treatment on its progress has been noted.