Effects of substituents on the chlorination of methyl 3‐hydroxythiophene‐2‐carboxylate and on the reaction of the resulting chlorinated products with active hydrogen containing compounds

Abstract

Abstract The title tandem reactions that produce 5‐substituted compounds of methyl 3‐hydroxythiophene‐2‐carboxylate can also be applied with a minor modification to the 4‐alkyl and 4‐aryl derivatives thereof. On the other hand, 5‐alkyl and 5‐aryl derivatives that undergo a similar smooth chlorination behave in the second reaction in a different manner.