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Total synthesis of heptacyclic Aspidosperma alkaloids. Part 1. Preliminary experiments
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1987
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Combinatorial ChemistryMedicinal ChemistryBiosynthesisBioorganic ChemistryNatural Product SynthesisBiochemistryObscurinervidine AnalogueMedicineNatural SciencesTotal SynthesisPenultimate IntermediateStereoselective SynthesisPharmacologySynthetic ChemistryEnantioselective SynthesisDrug DiscoveryModel ExperimentsDrug Analysis
A series of model experiments is described, in which methods for the construction of the alkaloids of the obscurinervine group are developed. The penultimate intermediate (44) in a synthesis of the obscurinervidine analogue lacking only the aromatic methoxy groups has been prepared.