Toward the Total Synthesis of Disorazole A₁ and C₁: Asymmetric Synthesis of a Masked Southern Segment

Abstract

[reaction: see text] A highly convergent asymmetric synthesis of the masked southern segment of the antimitotic agent disorazole A(1) involves a Sonogashira coupling between a C1'-C10' enyne and a suitably protected C11'-C19' vinyl iodide. The central E,Z,Z-triene moiety is masked as a more stable ynediene.