High Prevalence of the Connexin 26 (GJB2) Mutation in Chinese Cochlear Implant Recipients

Abstract

The 235delC mutation was the most prevalent mutation, found in 18.3% (42/230 alleles) of all cochlear implant recipients and 21.0% (42/200 alleles) of the non-syndromic deafness group. Only 0.6% of GJB2 mutations were detected in the inner ear malformation group. The novel 187G-->T mutations are likely to be pathological mutations.