TCF7L2 rs7903146 impairs islet function and morphology in non-diabetic individuals

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

Valeriya Lyssenko, R Lupi, Piero Marchetti et al. · Journal of Clinical Investigation · 2007 · 831 citations · Full text

Medicine, Endocrinology, Genetics +17

Selective β-Cell Loss and α-Cell Expansion in Patients with Type 2 Diabetes Mellitus in Korea

Kun‐Ho Yoon, Seung‐Hyun Ko, Jae‐Hyoung Cho et al. · The Journal of Clinical Endocrinology & Metabolism · 2003 · 649 citations · Full text

Medicine, Cell Biology, Endocrinology +17

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms

Silke Schäfer, Otto Tschritter, Fausto Machicao et al. · Diabetologia · 2007 · 306 citations · Full text

Life Sciences, Endocrinology, Genetics +14

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

Luan Shu, Aleksey V. Matveyenko, Julie Kerr‐Conte et al. · Human Molecular Genetics · 2009 · 274 citations · Full text

Life Sciences, Endocrinology, Molecular Biology +17

Reduced Insulin Exocytosis in Human Pancreatic β-Cells With Gene Variants Linked to Type 2 Diabetes

Anders H. Rosengren, Matthias Braun, Taman Mahdi et al. · Diabetes · 2012 · 237 citations · Full text

Medicine, Endocrinology, Genetics +13