Nitric oxide donors rescue diabetic nephropathy through oxidative‐stress‐ and nitrosative‐stress‐mediated Wnt signaling pathways

Abstract

NO donor treatment alleviates extracellular matrix accumulation and apoptosis in diabetic nephropathy in vivo by not only preventing the diabetes-mediated oxidative and nitrostative stress, but also restoring downregulation of endothelial NO synthase expression and Wnt/β-catenin signaling. These findings suggest that modulation of NO is a viable alternative strategy for rescuing diabetic renal injury.