Quantitative proton-decoupled ³¹ P MRS and ¹ H MRS in the evaluation of Huntington's and Parkinson's diseases

Abstract

Previously described failure of global energy metabolism in HD was not confirmed. However, quantitative 1-hydrogen MRS and decoupled 31-phosphorus MRS are sensitive to +/-10% alterations in key cerebral metabolites, and may be of value in noninvasive monitoring of appropriate therapies.