Penetration of Clindamycin into Bone in Man

Abstract

Clindamycin (7-chloro-7-deoxylincomycin-hydrochloride-monohydrate) is an antibiotic with a remarkable bacteriostatic and bactericidal activity against staphylococci [1, 4, 5, 8]. It may, therefore, be regarded as one of the drugs suited for therapy of staphylococcal osteomyelitis, especially after very good efficacy of Lincomycin was recorded in this disease. To confirm this assumption, however, the data on penetration of Clindamycin into the bone under conditions of routine clinical practice are needed above all. This study presents the preliminary results obtained in this respect.