Biochemistry of 1,3-butadiene metabolism and its relevance to 1,3-butadiene-induced carcinogenicity

Comparison of the biotransformation of 1,3-butadiene and its metabolite, butadiene monoepoxide, by hepatic and pulmonary tissues from humans, rats and mice

György A. Csanády, F.Peter Guengerich, James A. Bond · Carcinogenesis · 1992 · 252 citations · Full text

Pharmacy, Biochemistry, Toxicology +12

Carcinogenicity of 1,3-butadiene in C57BL/6 x C3H F1 mice at low exposure concentrations.

R L Melnick, J Huff, Billy J. Chou et al. · PubMed · 1990 · 235 citations

Medicine, Oncology, Toxicology +14

Inhalation Toxicity Studies With 1,3-Butadiene 3 Two Year Toxicity/Carcinogenicity Study in Rats

P E Owen, J.R. Glaister, I.F. Gaunt et al. · American Industrial Hygiene Association Journal · 1987 · 222 citations

Pharmacy, Toxicology, Comparative Toxicology +12

Identification of the human liver cytochrome <i>P</i>-450 responsible for coumarin 7-hydroxylase activity

J S Miles, Aileen McLaren, Lesley M. Forrester et al. · Biochemical Journal · 1990 · 191 citations · Full text

Medicine, Biochemistry, Pharmacology +14

Human Liver Microsomes Are Efficient Catalysts of 1,3-Butadiene Oxidation: Evidence for Major Roles by Cytochromes P450 2A6 and 2E1

Renee J. Duescher, Adnan A. Elfarra · Archives of Biochemistry and Biophysics · 1994 · 158 citations

Life Sciences, Biochemistry, Chemistry +14