Effect of lignocaine on conducting system of human heart.

Abstract

The effects of lignocaine on atrioventricular conduction, particularly in relation to pre-existing disease of the specialized conducting tissues, were studied. Ten patients, 7 of whom had symptomatic coronary heart disease, were selected, and 4 hadfirst-degree His-Purkinje system (HPS) block (HV interval > 55 msec). His bundle electrograms were recorded in each patient: (i) under basic resting conditions (basic tracings), (2) during stressing of the conducting system by atrial pacing at rates from 8o to i5o beats per minute (control tracings),