An environmentally benign and efficient synthesis of 2-thio-substituted benzothiazoles

Abstract

An environmentally benign, simple and highly efficient method for the synthesis of 2-thio-substituted benzothiazole derivatives has been achieved in good to excellent yields by reacting a series of aryl halides with 2-mercapto benzothiazole, using recyclable CuFe2O4 nanoparticles under ligand free conditions in PEG-400 as solvent. In the present protocol, the copper ferrite nanoparticles can be recovered and reused up to four cycles without significant loss of activity.