Immunohistochemical localization of phosphorylated AKT in multiple myeloma

Abstract

We read with interest the article by Hsu et al[1][1]analyzing the activation status of AKT in plasma cells from patients with multiple myeloma (MM) or monoclonal gammopathy of undetermined significance (MGUS). Recent studies based on MM cell lines indicate that the phosphatidylinositol 3–kinase (