The 5HTTLPR polymorphism, psychopathologic symptoms, and platelet [³H-] paroxetine binding in bulimic syndromes

Abstract

Our results suggest that proneness to impulsivity, affective dysregulation, and reduced central 5-HT reuptake may (in part) be codetermined by the 5HTTLPR polymorphism. However, given inconsistent 5HTTLPR expression in different populations, we speculate that we may be observing a phenotype (i.e., eating disorder)-dependent manifestation.