Cadmium(II) complex with 2-methyl-1H-4,5-imidazoledicarboxylic acid ligand: synthesis, characterization, and biological activity

Abstract

AbstractA coordination polymer, [Cd(L)2(H2O)2]n (HL = 2-methyl-1H-4,5-imidazoledicarboxylic acid), was prepared from reactions of Cd(NO3)2 with L at room temperature. It was characterized by IR spectra and elemental analysis. The complex was structurally characterized by X-ray single-crystal diffraction revealing that the complex crystallizes in monoclinic with P2(1)/c space group, a = 12.203(10) Å, b = 9.332(8) Å, c = 7.554(7) Å, β = 100.894(2) Å, V = 844.7(13) Å3, Z = 2. Fluorescence and UV absorption spectroscopy indicated that the complex can bind to fish sperm DNA. Gel electrophoresis assay demonstrated the ability to cleave the HL-60 plasmid DNA. Apoptotic study showed that the complex exhibited significant cancer cell (JEKO and KB) inhibitory rate.Complex binding to DNA in an intercalative modeKeywords: Cd(II) complexDNA bindingBiological activity AcknowledgementsWe gratefully acknowledge the Natural Science Foundation of China [grant number 21171118], the Distinguished Professor Project of Liaoning province and the science and technology special fund of Shenyang City (F12-151-9-00).