Evolving Carbapenemases: Can Medicinal Chemists Advance One Step Ahead of the Coming Storm?

Abstract

ADVERTISEMENT RETURN TO ISSUEPREVPerspectiveNEXTEvolving Carbapenemases: Can Medicinal Chemists Advance One Step Ahead of the Coming Storm?Peter Oelschlaeger*†, Ni Ai‡, Kevin T. DuPrez†, William J. Welsh‡, and Jeffrey H. Toney§View Author Information† Chemistry Department and Center for Macromolecular Modeling and Materials Design, California State Polytechnic University, Pomona, California‡ Department of Pharmacology, Robert Wood Johnson Medical School and Informatics Institute, University of Medicine and Dentistry of New Jersey and Environmental Bioinformatics and Computational Toxicology Center, Piscataway, New Jersey§ College of Natural, Applied and Health Sciences, Kean University, Union, New Jersey*To whom correspondence should be addressed. Phone: 909-869-3693. Fax: 909-869-4344. E-mail: [email protected]Cite this: J. Med. Chem. 2010, 53, 8, 3013–3027Publication Date (Web):February 1, 2010Publication History Received28 August 2009Published online1 February 2010Published inissue 22 April 2010https://doi.org/10.1021/jm9012938Copyright © 2010 American Chemical SocietyRequest reuse permissionsArticle Views2724Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (4 MB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Antimicrobial agents,Bacteria,Inhibitors,Ions,Peptides and proteins Get e-Alerts