Influence of <i><scp>CYP</scp>2<scp>C</scp>8*2</i> on the Pharmacokinetics of Pioglitazone in Healthy African‐American Volunteers

Abstract

These data suggest that CYP2C8*2 influences pioglitazone pharmacokinetics in vivo, particularly the AUC0-48 ratio of M-III:parent drug, and the AUC0-48 ratio of M-III:M-IV. Larger studies are needed to further investigate the impact of CYP2C8*2 on the pharmacokinetics of CYP2C8 substrates in individuals of African descent.