Reduced Sodium Pump α₁, α₃, and β₁-Isoform Protein Levels and Na⁺,K⁺-ATPase Activity but Unchanged Na⁺-Ca²⁺Exchanger Protein Levels in Human Heart Failure

Abstract

The enhanced sensitivity of failing human myocardium toward cardiac glycosides may be, at least in part, attributed to a reduced protein expression and activity of the sarcolemmal Na+,K+-ATPase without a change in Na+-Ca2+ exchanger protein expression.