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A Short and Efficient Synthesis of the Pharmacological Research Tool GW501516 for the Peroxisome Proliferator-Activated Receptor δ
63
Citations
15
References
2003
Year
Key StepMolecular PharmacologyMedicinal ChemistryPharmaceutical ScienceBiochemistryMedicineMercaptophenol 5Natural SciencesMechanism Of ActionAgonist Gw501516Experimental PharmacologyPharmacotherapyEfficient SynthesisChemical BiologyPharmacologyPharmaceutical ChemistryDrug Discovery
The most potent and selective peroxisome proliferator-activated receptor delta (PPARdelta) agonist GW501516 (1) was synthesized in 4 steps and 78% overall yield starting from o-cresol by using a one-pot regiocontrolled dialkylation of mercaptophenol 5 as the key step.
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