Publication | Closed Access
An Efficient Synthesis of Dialkyl 2-Oxoalkanephosphonates and Diphenyl-2-oxoalkylphosphine Oxides from 1-Chloralkyl Ketones
43
Citations
0
References
1985
Year
EngineeringOrganic ChemistryEfficient SynthesisChemistryHeterocycle ChemistryStereoselective SynthesisDiphenyl-2-oxoalkyl-phosphine OxidesDialkyl 2-OxoalkanephosphonatesTrialkyl PhosphitesDiversity-oriented Synthesis1-Chloralkyl KetonesDiphenyl-2-oxoalkylphosphine OxidesCatalysisPharmacologyEnantioselective SynthesisHeterocyclicNatural SciencesDerivative (Chemistry)Synthetic Chemistry
The synthesis of dialkyl 2-oxoalkanephosphonates and diphenyl-2-oxoalkyl-phosphine oxides, via an Arbuzov reaction of trialkyl phosphites or ethoxydiphenylphosphine with methoxycarbonylhydrazono derivatives of 1-chloroalkyl ketones followed by carbonyl deprotection, is described.