The arthritis severity locus<i>Cia5d</i>is a novel genetic regulator of the invasive properties of synovial fibroblasts

Abstract

These data represent the first evidence for a genetic component in the regulation of FLS invasion. A gene located within the Cia5d interval accounts for this effect and operates via the regulation of soluble MT1-MMP production and MMP-2 activation. These observations suggest novel potential pathways for prognostication and therapy.