Publication | Closed Access
Subclinical cerebellar impairment in the common types of migraine: A three‐dimensional analysis of reaching movements
107
Citations
19
References
2001
Year
Neurological DisorderGeneticsSynaptic TransmissionMotor ControlCellular NeurobiologySynaptic SignalingCommon TypesCacna1a GeneNeurobiology Of DiseaseSubclinical Cerebellar ImpairmentNeurologyThree‐dimensional AnalysisMigraine NeedsNeurorehabilitationMotor DisorderNeurogeneticsHealth SciencesMedicineIon ChannelsSensorimotor IntegrationNeurological DiseaseMovement DisordersPointing ParadigmSynaptic PlasticityNeurophysiologyMotor SystemNeuroscienceMolecular NeurobiologyCentral Nervous SystemFine Motor Control
Abstract Mutations in the CACNA1A gene can cause familial hemiplegic migraine (FHM) and/or cerebellar ataxia. CACNA1A codes for the α 1 subunit of P/Q‐Ca 2+ channels and is highly expressed in the cerebellum. Using a pointing paradigm and infrared optoelectronic tracking system, we found subclinical hypermetria and other subtle cerebellar signs in the common forms of migraine. These were more pronounced in migraine with than without aura. Whether this reflects involvement of Ca 2+ channel genes in the common types of migraine needs to be investigated by genetic analyses.
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