Physically Associated Synthetic Hydrogels with Long‐Term Covalent Stabilization for Cell Culture and Stem Cell Transplantation

Abstract

Poly(ethylene glycol)-poly(propylene sulfide) (PEG-PPS) hydrogels are injectable synthetic non-protease degradable hydrogels that allow cell spreading and proliferation in vitro and cellular infiltration in vivo. Further, this hydrogel promotes the survival of transplanted neural progenitor cells in the brain. PEG-PPS hydrogels form through a combination of hydrophobic interactions between the PPS domains and covalent bonds through disulfide exchange reactions of the polymer end groups. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.