Reproducibility of Diabetic Macular Edema Estimates From SD-OCT Is Affected by the Choice of Image Analysis Algorithm

Abstract

The Iowa Reference Algorithm and the Spectralis software provide excellent reproducibility between serial scans in patients with clinically significant DME. The publicly available Iowa Reference Algorithm may have lower between-measurement variation than the manufacturer-supplied Spectralis software for the central 3 mm subfield. These findings have significant implications for the management of patients with DME.