Preoperative Factors Affecting Tympanic Membrane Regeneration Therapy Using an Atelocollagen and Basic Fibroblast Growth Factor

Abstract

Tympanic membrane regeneration therapy can be applied to all patients, except those with cholesteatoma or malignant neoplasm. However, patients with severe calcification of the TM and those with marginal perforations close to the fibrous annulus should be treated more prudently to achieve perforation closure.