Concepedia

Apelin Inhibits Insulin Secretion in Pancreatic β-Cells by Activation of PI3-Kinase-Phosphodiesterase 3B

Lin Guo, Qiang Li, Wei Wang, Ping Yü, Hongyan Pan, Pengjie Li, Yuqian Sun, Jinchao Zhang

Endocrine Research · 2009 · 78 citations · 23 references

DOI

Abstract

These findings suggest that apelin exerts direct inhibitory actions on the pancreatic beta-cells by activating PI3-kinase-dependent PDE3B and subsequently suppressing of cAMP levels.

References

23

Isolation and Characterization of a Novel Endogenous Peptide Ligand for the Human APJ Receptor

Kazuhiko Tatemoto, Masaki Hosoya, Yugo Habata et al. · Biochemical and Biophysical Research Communications · 1998 · 1.7K citations

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Apelin, a Newly Identified Adipokine Up-Regulated by Insulin and Obesity

Jérémie Boucher, Bernard Masri, Danièle Daviaud et al. · Endocrinology · 2005 · 874 citations

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A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11

Brian F. O’Dowd, Michael Heiber, Audrey Chan et al. · Gene · 1993 · 832 citations

, , +11

Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

Malcolm Whitman, David R. Kaplan, Brian Schaffhausen et al. · Nature · 1985 · 825 citations

, , +9

The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism

Kazuhiko Tatemoto, Kiyoshige Takayama, Min‐Xu Zou et al. · Regulatory Peptides · 2001 · 639 citations

, , +8