Preparation of Polyfunctional Arynes via 2‐Magnesiated Diaryl Sulfonates

Abstract

The synthetic potential of arynes can be exploited through a new method for their generation from functionalized aryl magnesium reagents and controlled reaction. Arynes with functional groups such as ester, nitrile, ketone, or nitro groups, or with a quinolyl skeleton, can be formed from polyfunctionalized 2-iodo aryl 4-chlorobenezenesulfonates and trapped in 68–93 % yield with furan (see scheme). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z460417_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.