Phosphoinositide 3-Kinase/Protein Kinase B Signaling Pathway Is Involved in Estradiol 17β-D-Glucuronide–Induced Cholestasis: Complementarity with Classical Protein Kinase C

Abstract

The PI3K/Akt signaling pathway is involved in the biliary secretory failure induced by E(2)17G through sustained internalization of canalicular transporters endocytosed via cPKC.