Antiinflammatory constituents of teramnus labialis

Abstract

Bioassay-guided fractionation, based on antiinflammatory activity of the methanolic extractives of Teramnus labialis led to the isolation and characterization of vitexin, bergenin, daidzin and 3-O-methyl-D- chiro -inositol as active constituents. Vitexin exhibited a dose-dependent inhibitory activity on 5-lipoxygenase enzyme. The isolated constituents were also screened for their antioxidant activity by nitroblue tetrazolium (NBT) riboflavin photo reduction method. Vitexin exhibited moderate antioxidant activity. This is the first reported occurrence of vitexin, bergenin, daidzin and 3-O-methyl-D- chiro -inositol in T. labialis.