Scandinavian Journal of Clinical and Laboratory Investigation · 1972 · 56 citations · 13 references
MedicineBiochemistryPathologyClinical BiochemistryHepatologyProtein BiochemistryChronic Liver DiseaseHepatic ImpairmentLiver DiseaseLiver Function TestsLiver PhysiologyPlasma ProteinsAcute Phase ReactantsAcute-phase ProteinsCirrhosis Biochemistry MarkersLiver Disease-related Protein ChangesPlasma In Liver DiseasePlasma Protein BiomarkersPlasma Protein SynthesisSerum Total Protein
In 40 cases of liver cirrhosis in a quiescent state the plasma level of 21 proteins was determined. The acute phase reactants, haptoglobins and orosomucoid were normal or decreased, while α1-antitrypsin, fibrinogen and C-reactive protein were slightly increased or normal. Prealbumin, prothrombin and β2-glycoprotein I were most frequently subnormal. Of the plasma proteins studied prealbumin seemed to be the most sensitive indicator of the impaired liver function. The mean α2 -macroglobulin, IgA and IgG were doubled but in many cases the values were normal. a2-macroglobulin and albumin synthesized in the liver seemed to vary independently of each other also in hypoalbuminemia.
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