Publication | Closed Access
The Anesthetic Potency of Lidocaine in the Rat
37
Citations
0
References
1976
Year
Anesthetic EffectAnesthetic MechanismPharmacotherapyAnesthetic PotencyMolecular PharmacologyPain ManagementHealth SciencesNeuropharmacologyLocal Anesthetic PharmacologyNervous SystemPharmacologyAnaesthetic AgentMaximum Mac FractionNeurophysiologyPhysiologyAnesthesiaMedicineCyclopropane MacAnesthesiology
The anesthetic effect of lidocaine was evaluated in rats by determining the change in anesthetic requirement of cyclopropane MAC that was produced by blood concentrations of lidocaine in the clinically useful range. A linear reduction in anesthetic requirement was produced with concentrations up to 1 mug/ml. Further increases in lidocaine up to 5.5 mug/ml resulted in no further decrease in cyclopropane requirement. Lidocaine was found to contribute a maximum MAC fraction of 0.4.