Concepedia

Effects of ABT‐229, a motilin agonist, on acid reflux, oesophageal motility and gastric emptying in patients with gastro‐oesophageal reflux disease

Peter Netzer, Brenda Landvoigt Schmitt, W. Inauen

Alimentary Pharmacology & Therapeutics · 2002 · 29 citations · 41 references

DOIFull text

Open access

Abstract

ABT-229 is able to reduce slightly, but significantly, acid reflux in patients with gastro-oesophageal reflux disease. This effect does not appear to be due to a measurable improvement in oesophageal motility or gastric emptying.

References

41

Measurement of gastric emptying rate of solids by means of a carbon-labeled octanoic acid breath test

Yvo Ghoos, Bart Maes, Benny Geypens et al. · Gastroenterology · 1993 · 946 citations

, , +5

Improvement of Gastric Emptying in Diabetic Gastroparesis by Erythromycin

J. Janssens, T. L. Peeters, G. Vantrappen et al. · New England Journal of Medicine · 1990 · 757 citations · Full text

Ambulatory 24-h esophageal pH monitoring: normal values, optimal thresholds, specificity, sensitivity, and reproducibility.

John R. Jamieson, H. J. Stein, Tom R. DeMeester et al. · PubMed · 1992 · 498 citations

, , +13

Gastric emptying in patients with gastroesophageal reflux

Richard W. McCallum, David Berkowitz, Emanuel Lerner · Gastroenterology · 1981 · 410 citations

, , +2

Receptor for Motilin Identified in the Human Gastrointestinal System

Scott D. Feighner, Carina P. Tan, Karen K. McKee et al. · Science · 1999 · 403 citations

, , +15