Effects of recombinant human osteogenic protein 1 on the production of proteoglycan, prostaglandin E₂, and interleukin‐1 receptor antagonist by human articular chondrocytes cultured in the presence of interleukin‐1β

Abstract

Treatment of human articular chondrocytes with OP-1 cultured in the presence of FBS is effective in overcoming the down-regulation of proteoglycan synthesis induced by low doses of IL-1beta.