Science · 1977 · 47 citations · 10 references
Life SciencesNeurobiologyNeuroscienceHormone BiochemistryNeurochemistryNeuroendocrinologyGrowth HormoneGrowth Hormone RegulationHormone SecretionHypothalamic-pituitary AxisMammalian EndocrinologyNeuroendocrine PhysiologyElectron LocalizationEndocrine Cell Secretory GranulesHypothalamic Hormone SecretionHypothalamic HormonesHypothalamic NeurosecretionHypothalamic-pituitary-growth AxisImmunohistochemical StainingSomatostatin-mediated Inhibition
Somatostatin, the hypothalamic hormone which inhibits the secretion of growth hormone by the pituitary, has been localized in the rat hypothalamus by using electron microscope immunohistochemistry. Somatostatin occurs in secretory granules (80 to 110 nm in diameter) of a few neurons located in the hypothalamic periventricular nucleus. These observations establish the identity of neurosecretory neurons involved in the regulation of adenohypophyseal secretion.
10
Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone
Paul Brazeau, Wylie Vale, Roger Burgus et al. · Science · 1973 · 3.5K citations
Radioimmunoassay for GH-Release Inhibiting Hormone
A. Arimura, Hideko Sato, D. H. Coy et al. · Experimental Biology and Medicine · 1975 · 303 citations