Mn(OAc)₃-mediated synthesis of β-hydroxyphosphonates from P(O)–H compounds and alkenes

Abstract

A new and general method for the synthesis of β-hydroxy phosphonates has been achieved through Mn(OAc)3-mediated radical oxidative phosphonation of alkenes with H-phosphonates and H-phosphine oxide. The starting materials of P(O)–H compounds and alkenes are stable and cheap. Mn(OAc)3 can be readily prepared from Mn(OAc)2 in the laboratory. This method can be easily adapted to large-scale preparations.