Structures of ent-herbertane sesquiterpenoids displaying antifungal properties from the liverwort Herberta adunca

Abstract

Several aromatic sesquiterpenoids displaying antifungal properties have been isolated from the liverwort Herberta adunca together with a mother hydrocarbon with a novel irregular sesquiterpene skeleton, ent-herbertane, and their structures and absolute configurations have been determined on the basis of extensive degradation reactions and spectroscopic evidence. The biological activity is also described.