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Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein quantification and PBPK modeling

Translational MedicineHepatologyCarrier-mediated Hepatic DispositionLiver PhysiologyBioanalysisMedicineHepatitisPathologyHepatotoxicityPbpk ModelingPharmacologyPhysiologically-based Pharmacokinetic ModelingDrug-induced Liver InjuryPharmacokinetics