Journal of Toxicology Clinical Toxicology · 2002 · 52 citations · 36 references
MedicinePharmacologyPharmacotherapyEpilepsyEpileptologyNeuropharmacologyBipolar Disorder PharmacotherapyDrug-resistant EpilepsyElectroencephalography In EpilepsySeizure DisordersSeizure ManagementStatus EpilepticusBipolar Disorder AssociationCarbamazepine PharmacologyComplications Of Status EpilepticusSeizuresStatus Epilepticus ElectroencephalographyStatus Epilepticus In EpilepsyStatus Epilepticus PharmacotherapyStatus Epilepticus Treatment
We report two patients who experienced status epilepticus after carbamazepine overdose. The first patient was an 18-year-old female with a history of epilepsy. She experienced 4 hour of persistent and prolonged seizures resistant to sodium amytal therapy. The status epilepticus ended with her death. The second patient was an 18-year-old male with a history of bipolar disorder. He experienced 5 hour of persistent and prolonged seizures that appeared to be resistant to diazepam, phenytoin, and phenobarbital. The seizures abated with the infusion of midazolam. This is a report of status epilepticus associated with wide complex tachycardia after carbamazepine overdose, which may be resistant to conventional therapy.
36