Concepedia

Publication | Open Access

Carvedilol but Not Metoprolol Reduces β-Adrenergic Responsiveness After Complete Elimination From Plasma In Vivo

DOIFull Paper Access

60

Citations

21

References

2004

Year

Michael Kindermann, Christoph Maack, Susanne Schaller, Nadine Finkler, K. Schmidt, Stephanie Läer, H Wuttke, Hans‐Joachim Schäfers, Michael Böhm
Circulation

Abstract

Carvedilol but not metoprolol inhibits the catecholamine response of the human heart beyond its plasma elimination. The persistent beta-blockade by carvedilol may be explained by binding of carvedilol to an allosteric site of beta-ARs.

References

YearCitations

Page 1