Life SciencesImmunologyPhysiologyImmunopathologyInflammationInnate ImmunityDisease MechanismsFever ManagementHeat StressPathogenesis Of Infectious DiseaseThermal PhysiologyCellular Heat Shock ResponseHeat Shock Response
The second edition of Dr Mackowiak’s monograph on fever, released six years after the first, expands from 20 to 37 chapters and incorporates new molecular biology advances while retaining the original thermometry chapters. The book’s mechanism section covers cytokines, prostaglandin E₂, heat‑shock proteins, and other entities, and includes a chapter on fever’s role in host defense that informs future debates on symptomatic treatment. Many clinical chapters have been updated, and the basic mechanisms portion has been thoroughly revised to a first‑class standard. References span publications up to the present.
The second edition of Dr Mackowiak's comprehensive monograph on fever appears 6 years after the first. This edition is even more comprehensive, containing 37 chapters, compared with 20 in the first edition, and adds chapters on new advances, mainly in molecular biology. Many, but not all, of the clinical chapters have been updated. The initial chapters on the history of thermometry are interesting, informative, and well written and remain pretty much as they were in the first edition. The basic mechanisms portion of the book has been thoroughly updated and is first class. It includes chapters on cytokines as endogenous pyrogens, prostaglandin E<sub>2</sub>, heat shock proteins, and many other entities. Jeffrey Hasday contributes an interesting chapter about the influence of fever on host defense, laying the foundation for discussions in future chapters of whether fever should be treated symptomatically. The references, for the most part, include publications through the